This case report details the treatment of a patient with stage IV poorly differentiated pancreatic ductal adenocarcinoma (PDA) using intravenous pharmacologic ascorbic acid (PAA) as the sole therapy. The patient survived nearly four years post-diagnosis, exhibiting objective tumor regression and stable disease, as evidenced by serial CT/PET imaging. The proposed
This 2012 study explored how re-oxygenation impacts hypoxic tumors by restoring wild-type functionality to p53, a key tumor suppressor often rendered inactive under low oxygen conditions. Under hypoxia, p53 assumes a mutant-like conformation that diminishes its transcriptional and tumor-suppressive activities. Re-oxygenation with 30% oxygen at normobaric pressure reversed these effects
This study evaluates the use of Viscum album extract (Isorel) as an adjuvant cancer biotherapy, reporting its benefits in combination with conventional treatments like surgery and radiotherapy. The study found that Isorel helped prevent tumor recurrence in 47% of patients, led to tumor regression in 38%, and showed no health
