This 2012 review by Moen and Stuhr examines the effects of hyperbaric oxygen therapy (HBOT) on cancer progression, focusing on studies from 2004 to 2012. The authors found no evidence that HBOT stimulates tumor growth or recurrence. Instead, HBOT may inhibit tumor growth in certain cancer subtypes, such as breast
This 2015 study explores the potential of artesunate (ART), an anti-malarial drug, as a treatment for metastatic renal cell carcinoma (RCC). Analysis of patient data revealed that high expression of transferrin receptor 1 (TfR1), a marker associated with ART sensitivity, correlated with distant metastasis and poor prognosis in clear cell
This study investigates the anticancer activity of an aqueous mistletoe extract (AME) in syngeneic murine tumor models. The results show that AME inhibits tumor growth and enhances immune response, suggesting its potential as an alternative or complementary cancer therapy. The study discusses the mechanisms underlying AME’s anticancer effects, including its
This minireview summarizes the antitumor properties of betulinic acid, a naturally occurring phytochemical. It discusses the compound’s multifaceted mechanisms, including its ability to induce apoptosis, inhibit angiogenesis, and suppress tumor growth. The review highlights betulinic acid’s potential as a potent anticancer agent, with a focus on its role in targeting
This article reviews the potential role of statins, metformin, and bisphosphonates in cancer prevention. The study examines the mechanisms by which these agents, commonly used for cardiovascular, metabolic, and bone health, may reduce cancer risk. Statins may inhibit tumor growth by targeting cholesterol synthesis pathways, metformin by affecting insulin and
This review article discusses the potential use of growth-hormone-releasing hormone (GHRH) antagonists in cancer therapy. GHRH antagonists have been shown to inhibit the growth of various human cancer lines, including breast, ovarian, prostate, lung, brain, and other cancers, in xenograft models. The therapeutic action is primarily through blocking the autocrine/paracrine
This review explores the potential of methionine restriction as a therapeutic strategy for cancer treatment, particularly for tumors dependent on methionine. It discusses how methionine restriction, either through dietary changes or enzymatic depletion (e.g., methioninase), inhibits tumor cell growth, especially in cancers with methylthioadenosine phosphorylase (MTAP) deficiency. The article also
This observational study assessed the safety and adverse drug reactions (ADRs) of subcutaneous mistletoe (Viscum album) extract in cancer patients. A total of 1,923 patients receiving mistletoe as part of anthroposophic medicine were observed, with 14.7% reporting expected effects such as local reactions and mild fever. Only 8.4% of patients
