Well Referenced

Tag: triiodothyronine

Does Thyroid Hormone Have a Role as Adjunctive Therapy in Depression?

This 1996 review by I.M. Jackson evaluates the evidence supporting the use of thyroid hormones—particularly triiodothyronine (T3)—as adjunctive therapy in depression. The review highlights that hypothyroidism is commonly associated with depressive symptoms and should be treated with levothyroxine (T4). T3 has been shown to accelerate or enhance the response to

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June 26, 2025 No Comments

Thyroid Hormone and Hair Growth

This 2000 editorial by A.G. Messenger outlines the physiological influence of thyroid hormones on hair follicle biology. Although it does not provide empirical data, it highlights the clinical observation that both hypothyroidism and hyperthyroidism can lead to hair disorders, including diffuse hair thinning and alopecia. Thyroid hormones, primarily triiodothyronine (T3)

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June 26, 2025 No Comments

Hormonal Correlates and Thermoregulatory Consequences of Molting on Metabolic Rate in a Northerly Wintering Shorebird

This 2009 physiological study examined how molting affects metabolic rate and thermoregulation in the red knot (Calidris canutus islandica), a shorebird wintering in cold climates. Molting birds showed a 9.8% increase in mass-independent basal metabolic rate (BMR) compared to nonmolting individuals. Thyroxine (T₄) levels were positively correlated with the rate

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June 26, 2025 No Comments

The Effects of Thyroid Hormones on Brown Adipose Tissue in Humans: A PET-CT Study

This 2014 clinical investigation explored how thyroid hormones influence brown adipose tissue (BAT) activity in euthyroid human subjects using PET-CT imaging. Participants with higher circulating thyroid hormone levels, especially triiodothyronine (T3), demonstrated significantly increased glucose uptake in BAT, indicating heightened thermogenic activity. The study confirmed that thyroid hormones directly stimulate

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June 26, 2025 No Comments

A review of the safety of triiodothyronine in combination with levothyroxine for the management of hypothyroidism

This systematic review evaluates the safety of combining levothyroxine (LT4) and triiodothyronine (T3) for hypothyroidism treatment, particularly assessing the risk of thyrotoxicosis. Despite mixed evidence on clinical benefits, some patients report symptom improvement with LT4+T3 therapy. The review finds that safety concerns, especially regarding thyrotoxicosis, are minimal when LT4:T3 ratios

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June 26, 2025 No Comments

Benefits and Harms of Levothyroxine/L-Triiodothyronine Versus Levothyroxine Monotherapy for Adult Patients with Hypothyroidism: Systematic Review and Meta-Analysis

A systematic review and meta-analysis compared the effectiveness and safety of combined levothyroxine (LT4) and L-triiodothyronine (LT3) therapy versus LT4 monotherapy in adults with hypothyroidism. The study found no significant differences in clinical outcomes, including quality of life, psychological distress, depressive symptoms, and fatigue, between the two treatment methods. However,

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June 26, 2025 No Comments

A randomized trial of oral DHEA treatment for sexual function, well-being, and menopausal symptoms in postmenopausal women with low libido

This observational study explored the use of triiodothyronine (T3) therapy in hospitalized patients with hypothyroidism, demonstrating its effectiveness in rapidly normalizing thyroid hormone levels and improving clinical outcomes compared to levothyroxine (T4). The study found that T3 had a faster onset of action, making it particularly beneficial for critically ill

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June 26, 2025 No Comments

Conversion of thyroxine (T4) to triiodothyronine (T3) in athyreotic human subjects

The observational study titled “Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: a randomized controlled trial,” published in the Journal of Clinical Endocrinology & Metabolism (1970, PMID: 4986007), explored peripheral conversion of thyroxine (T4) to triiodothyronine (T3) in athyreotic (thyroid-removed) patients. The findings confirmed the body’s ability

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June 26, 2025 No Comments