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Tag: treatment-resistant ED

Systematic Review of Oral Combination Therapy for Erectile Dysfunction When Phosphodiesterase Type 5 Inhibitor Monotherapy Fails

​This systematic review, titled “Systematic Review of Oral Combination Therapy for Erectile Dysfunction When Phosphodiesterase Type 5 Inhibitor Monotherapy Fails,” published in Sexual Medicine Reviews in 2019 (PMID: 30711478), evaluated the efficacy and safety of second-line oral combination therapies for erectile dysfunction (ED) in patients unresponsive to phosphodiesterase type 5

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June 26, 2025 No Comments

Combination therapy with topical alprostadil and phosphodiesterase-5 inhibitors after failure of oral therapy in patients with erectile dysfunction: a prospective, two-arm, open-label, non-randomized study

This observational study evaluated the efficacy and safety of combining topical alprostadil with phosphodiesterase-5 inhibitors (PDE5-Is) in 139 men with erectile dysfunction (ED) unresponsive to PDE5-Is alone. The combination therapy significantly improved erectile function, with 70% of patients achieving successful intercourse compared to 30% using PDE5-Is alone (p

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June 26, 2025 No Comments