Well Referenced

Tag: translational research

Stuck at the bench: Potential natural neuroprotective compounds for concussion

This narrative review examines a range of natural compounds with potential neuroprotective effects in the context of concussion and mild traumatic brain injury (mTBI). Preclinical studies suggest that agents such as omega-3 fatty acids, curcumin, resveratrol, and green tea catechins exhibit anti-inflammatory, antioxidant, and neurorestorative properties that could mitigate post-concussive

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June 26, 2025 No Comments

Discussion: Growth Hormone Therapy Accelerates Axonal Regeneration, Promotes Motor Reinnervation, and Reduces Muscle Atrophy following Peripheral Nerve Injury

This 2016 expert commentary by Sando and Cederna discusses the implications of preclinical research by Tuffaha et al., which demonstrated that growth hormone (GH) therapy significantly enhances peripheral nerve regeneration in a rat model of sciatic nerve transection and repair. Daily subcutaneous administration of GH (0.4 mg/day) improved axonal regeneration,

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June 26, 2025 No Comments

Rapamycin and Ageing: When, for How Long, and How Much?

This 2014 review by Matt Kaeberlein evaluates critical variables in rapamycin use for aging interventions, including optimal dosing, treatment duration, and initiation timing. While rapamycin consistently extends lifespan in animal models, most studies employ a standard dose and continuous administration, potentially missing more effective strategies. Emerging evidence suggests intermittent or

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June 26, 2025 No Comments

Recent advances in biomarkers for senescence: Bridging basic research to clinic

This 2025 systematic review published in Geriatrics and Gerontology International (DOI: 10.1111/ggi.15054) explores the latest advances in biomarkers for cellular senescence, emphasizing their potential role in diagnosing and treating age-related diseases. The review discusses various biomarkers such as senescence-associated β-galactosidase, DNA-damage-related markers, and the senescence-associated secretory phenotype (SASP). It highlights

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June 26, 2025 No Comments