This 1998 study evaluated the effects of topical estradiol (0.01%) and estriol (0.3%) creams on skin aging in 59 perimenopausal women over six months. Both treatments significantly improved skin elasticity, firmness, and moisture, with reductions in wrinkle depth and pore size ranging from 61% to 100%. Immunohistochemical analysis revealed increased
This 2019 review discusses the impact of estrogen deficiency on skin aging in postmenopausal women, highlighting symptoms such as dryness, atrophy, fine wrinkling, and poor wound healing. The article evaluates topical treatments, including estrogen creams and soy-derived isoflavones like genistein, which interact with estrogen receptors in the skin. Clinical studies
This meta-analysis and expert panel discussion evaluated the safety of topical estrogen (TE) therapy in breast cancer survivors undergoing adjuvant endocrine treatment with tamoxifen (TAM) or aromatase inhibitors (AIs). Analyzing six observational studies with 38,050 patients, including 1,805 exposed to TE, the study found that TE use with TAM did
