The neurosteroid pregnenolone promotes degradation of key proteins in the innate immune signaling to suppress inflammation
The study investigated the neurosteroid pregnenolone and its ability to suppress inflammation by inducing ubiquitination and degradation of TIRAP and TLR2 in macrophages and microglial cells. This action led to decreased pro-inflammatory cytokine secretion, including tumor necrosis factor α and interleukin-6, through TLR2 and TLR4 pathways. Pregnenolone was also found
June 26, 2025
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