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Tag: thyroid hormone receptors

Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?

This review explores the potential of topical L-thyroxine (T4) in dermatology, highlighting its roles in skin physiology, wound healing, and hair growth. It discusses the mechanisms by which T4 influences epidermal and hair follicle functions, including modulation of keratin expression, mitochondrial activity, and stem cell behavior. The article emphasizes the

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June 26, 2025 No Comments

3,5-Diiodothyronine: A Novel Thyroid Hormone Metabolite and Potent Modulator of Energy Metabolism

This review explores the metabolic effects of 3,5-diiodo-L-thyronine (3,5-T2), an endogenous thyroid hormone metabolite. In rodent models, exogenous 3,5-T2 administration rapidly increases resting metabolic rate and induces beneficial hypolipidemic effects. The mechanisms are primarily non-genomic, targeting mitochondria to enhance oxidative phosphorylation and fatty acid oxidation. While some thyroid hormone receptor-mediated

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June 26, 2025 No Comments

Insight Into Molecular Determinants of T3 vs T4 Recognition From Mutations in Thyroid Hormone Receptor α and β

The study “Insight Into Molecular Determinants of T3 vs T4 Recognition From Mutations in Thyroid Hormone Receptor α and β” explores the structural mechanisms underlying the different affinities of triiodothyronine (T3) and thyroxine (T4) for thyroid hormone receptors (TRs). Researchers identified a novel M256T mutation in a patient with resistance

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June 26, 2025 No Comments