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Tag: therapeutic targeting

Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine

This Phase I clinical trial evaluated the safety and efficacy of methioninase (METase) and recombinant methioninase (rMETase) in depleting serum methionine (MET) levels in high-stage cancer patients. MET dependence is a metabolic vulnerability in cancer cells, making MET depletion a potential therapeutic strategy. Three patients received non-recombinant METase, showing significant

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June 26, 2025 No Comments

C-reactive protein: a target for therapy to reduce inflammation

This review article from Frontiers in Immunology explores the role of C-reactive protein (CRP) as a biomarker of inflammation and its potential as a therapeutic target in various chronic diseases such as cardiovascular disease, cancer, and autoimmune disorders. Elevated CRP levels have been linked to worse clinical outcomes, prompting interest

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June 26, 2025 No Comments