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Tag: therapeutic strategy

Iron Overload and Breast Cancer: Iron Chelation as a Potential Therapeutic Approach

This 2022 review explores the role of iron overload in breast cancer development and progression. Excess iron, particularly non-transferrin-bound iron (NTBI), can catalyze free radical reactions, leading to oxidative stress and DNA damage. Estrogen can exacerbate this by disrupting iron metabolism, further increasing reactive oxygen species (ROS) production. The study

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June 26, 2025 No Comments

Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

This article reviews the role of curcumin in promoting neurogenesis and providing neuroprotection in the context of brain ischemia and Alzheimer’s disease. It highlights how curcumin may enhance neurogenesis in the hippocampus and prevent neurodegeneration by reducing β-amyloid aggregation, a key factor in Alzheimer’s pathology. Curcumin has shown promise in

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June 26, 2025 No Comments