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Tag: therapeutic agent

Protective role of methylene blue in Alzheimer’s disease via mitochondria and cytochrome c oxidase

This observational study examined the protective role of methylene blue (MB) in Alzheimer’s disease (AD), demonstrating its potential as a therapeutic agent by enhancing mitochondrial function and acting as an antioxidant. MB improves cellular respiration and ATP production by serving as an alternative electron carrier, reduces oxidative stress, and provides

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June 26, 2025 No Comments

Role of DHEA in cardiovascular diseases

The article “Role of DHEA in cardiovascular diseases” (pubmed.ncbi.nlm.nih.gov) explores the potential of dehydroepiandrosterone (DHEA) as a therapeutic agent in cardiovascular conditions such as hypertension, coronary artery disease, atherosclerosis, and pulmonary hypertension. DHEA demonstrates anti-remodeling and vasorelaxant properties, mediated through membrane and nuclear receptors, ion channels, calcium signaling, and pathways

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June 26, 2025 No Comments

Curcumin Ameliorates Neuroinflammation, Neurodegeneration, and Memory Deficits in p25 Transgenic Mouse Model that Bears Hallmarks of Alzheimer’s Disease

This animal study investigated the effects of curcumin on neuroinflammation, neurodegeneration, and memory deficits in the p25 transgenic mouse model, which exhibits hallmarks of Alzheimer’s disease (AD). Curcumin treatment significantly improved memory performance, reduced neuroinflammatory markers, and decreased neuronal loss. Its neuroprotective effects were attributed to its ability to modulate

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June 26, 2025 No Comments

Extinction memory improvement by the metabolic enhancer methylene blue

This animal study examined the effects of methylene blue (MB), a metabolic enhancer, on extinction memory retention in rats. Results showed that MB-treated rats exhibited significantly lower freezing behavior in response to the conditioned stimulus, indicating improved retention of extinction memory. Additionally, MB increased brain cytochrome oxidase activity by 38%,

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June 26, 2025 No Comments

Progestogen use in women approaching the menopause and breast cancer risk

This study investigates the neuroprotective effects of progesterone in a rat model of focal cerebral ischemia. The findings show that progesterone helps preserve mitochondrial function and reduce neuronal damage following reperfusion, suggesting that it could be a promising therapeutic option for mitigating stroke-related brain injury. By maintaining mitochondrial integrity and

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June 26, 2025 No Comments