This 2017 review explores the role of oxidative stress and inflammation in telomere shortening, a key factor in cellular aging. It presents evidence that antioxidants (e.g., vitamins C and E, polyphenols) and anti-inflammatory agents (e.g., omega-3 fatty acids, statins) can mitigate telomere attrition by reducing oxidative damage and inflammatory responses.
This 2016 review examines the relationship between telomere dynamics and aging. It highlights that most human somatic cells exhibit irreversible telomere shortening with age, which is associated with aging-related diseases such as cancer, diabetes, and cognitive disorders. The authors discuss various methods for measuring telomere length, including quantitative fluorescence in
This 2012 review by Mikhelson and Gamaley posits that telomere shortening is the primary driver of aging in mammals. The authors argue that telomere attrition occurs with each cell division due to the DNA replication process, independent of oxidative damage. They contend that even in the absence of oxidative stress,
This 2004 study investigated the effects of L-carnosine, a naturally occurring dipeptide, on telomere dynamics in cultured human fetal lung fibroblasts. Cells continuously cultured with 20 mM L-carnosine exhibited a slower rate of telomere shortening and an extended replicative lifespan compared to controls. Additionally, non-dividing cells maintained in the presence
This 2014 review explores the relationship between leukocyte telomere length (LTL) and atherosclerosis, highlighting that shortened LTL is associated with cardiovascular aging. The study suggests that telomere attrition in hematopoietic stem cells (HSCs) due to chronic inflammation and oxidative stress contributes to endothelial dysfunction and plaque formation. It emphasizes that
