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Tag: telomere length

A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study

This 2015 randomized, double-blind, placebo-controlled study evaluated the effects of TA-65, a natural telomerase activator derived from Astragalus membranaceus, on telomere length in 117 cytomegalovirus-positive adults aged 53–87. Over 12 months, the low-dose group (250 units/day) experienced a significant telomere length increase (530 ± 180 bp; p=0.005), while the placebo

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June 26, 2025 No Comments

Telomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training

This 2016 review article examines the relationship between physical activity and telomere dynamics, highlighting how exercise can prevent telomere shortening—a key marker of biological aging—and reduce the risk of cardio-metabolic diseases. The authors discuss molecular mechanisms by which exercise influences telomere length, including the upregulation of telomerase activity and reduction

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June 26, 2025 No Comments

Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age

This 2022 review article explores various biomarkers and methodologies for assessing biological age, emphasizing the concept of aging clocks. It discusses the development and application of different types of aging clocks, including epigenetic clocks based on DNA methylation patterns, glycomic clocks analyzing glycan structures, and telomeric clocks measuring telomere length.

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June 26, 2025 No Comments

Identification of Telomerase-activating Blends From Naturally Occurring Compounds

This 2016 in vitro study evaluated the effects of various natural compounds and their combinations on telomerase activity in human lung fibroblast IMR90 cells. Individual compounds tested included α-lipoic acid, green tea extract, DMAE L-bitartrate, N-acetyl-L-cysteine, chlorella powder, L-carnosine, vitamin D3, rhodiola extract, glycine, French red wine extract, chia seed

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June 26, 2025 No Comments

Molecular and physiological manifestations and measurement of aging in humans

This 2017 review outlines the mechanisms of aging, emphasizing both molecular and physiological aspects. It discusses well-described molecular and cellular hallmarks and physiological changes of aging at the organ-system level. The authors propose methods to measure aging by integrating molecular biology (e.g., telomere length, epigenetic marks) and physiological function (e.g.,

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June 26, 2025 No Comments

Inflammatory age and its impact on age-related health in older Chinese adults

This observational study introduces the concept of inflammatory age (iAge) to quantify age-related inflammation and explores its relationship with various metabolic and cardiovascular conditions among older Chinese adults. Increased iAge correlated significantly with higher BMI, waist circumference, A1c levels, systolic blood pressure, triglycerides, and cardiovascular disease risk, as well as

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June 26, 2025 No Comments

The effect of hyperbaric oxygen therapy on cognition, performance, proteomics, and telomere length-The difference between zero and one: A case report

This case report examined the effects of hyperbaric oxygen therapy (HBOT) on cognitive function, physical performance, proteomic expression, and telomere length in a single adult male. After undergoing a series of HBOT sessions, the subject showed notable improvements in memory and executive function, enhanced physical endurance and strength, and proteomic

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June 26, 2025 No Comments

Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial

This study investigated the effects of hyperbaric oxygen therapy (HBOT) on telomere length and immunosenescence, showing that HBOT increased telomere length and reduced immune cell senescence in adults aged 50-80 years. With 40 sessions of HBOT over 2 months, the results suggested a significant enhancement in cellular aging and immune

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June 26, 2025 No Comments