Well Referenced

Tag: Telomere Attrition

Hormone-brain-aging relationships, broadly reactive with imidazole-containing dipeptides: targeting of telomere attrition as an aging biomarker and dynamic telomerase activity flirting

This 2015 review explores the potential of imidazole-containing dipeptides, such as carnosine and carcinine, in modulating telomere dynamics and telomerase activity to counteract cellular aging. The authors propose that these compounds may influence hormone-brain-aging interactions by affecting neurotransmission and oxidative stress pathways. Preliminary studies suggest that supplementation with these dipeptides

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June 26, 2025 No Comments

Melatonin and the theories of aging: a critical appraisal of melatonin’s role in antiaging mechanisms

This 2013 review critically examines melatonin’s role in aging, focusing on its interactions with oxidative stress, mitochondrial dysfunction, inflammaging, telomere attrition, and circadian rhythm disruption. Melatonin, a pleiotropic molecule, directly or indirectly influences these interconnected aging processes. The review highlights melatonin’s potential in mitigating age-related damage by enhancing antioxidant defenses,

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June 26, 2025 No Comments

Hallmarks of aging: An expanding universe

This 2023 review expands the original 2013 framework of nine hallmarks of aging to twelve, reflecting advances in aging research. The updated hallmarks are: (1) genomic instability, (2) telomere attrition, (3) epigenetic alterations, (4) loss of proteostasis, (5) disabled macroautophagy, (6) deregulated nutrient sensing, (7) mitochondrial dysfunction, (8) cellular senescence,

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June 26, 2025 No Comments