Tag: Telomerase

Telomere shortening is a sole mechanism of aging in mammals

This 2012 review by Mikhelson and Gamaley posits that telomere shortening is the primary driver of aging in mammals. The authors argue that telomere attrition occurs with each cell division due to the DNA replication process, independent of oxidative damage. They contend that even in the absence of oxidative stress,

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Telomere biology: Rationale for diagnostics and therapeutics in cancer

This 2015 review discusses the pivotal role of telomere biology in cancer development and its potential as a target for diagnostics and therapeutics. It highlights how telomere dysfunction enables malignant transformation by allowing cells to bypass the Hayflick limit, leading to uncontrolled proliferation. The article explores various components involved in

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