Well Referenced

Tag: telomerase activity

Telomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training

This 2016 review article examines the relationship between physical activity and telomere dynamics, highlighting how exercise can prevent telomere shortening—a key marker of biological aging—and reduce the risk of cardio-metabolic diseases. The authors discuss molecular mechanisms by which exercise influences telomere length, including the upregulation of telomerase activity and reduction

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June 26, 2025 No Comments

Hormone-brain-aging relationships, broadly reactive with imidazole-containing dipeptides: targeting of telomere attrition as an aging biomarker and dynamic telomerase activity flirting

This 2015 review explores the potential of imidazole-containing dipeptides, such as carnosine and carcinine, in modulating telomere dynamics and telomerase activity to counteract cellular aging. The authors propose that these compounds may influence hormone-brain-aging interactions by affecting neurotransmission and oxidative stress pathways. Preliminary studies suggest that supplementation with these dipeptides

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June 26, 2025 No Comments

Anti-aging protective effect of L-carnitine as clinical agent in regenerative medicine through increasing telomerase activity and change in the hTERT promoter CpG island methylation status of adipose tissue-derived mesenchymal stem cells

This in vitro study explored the anti-aging effects of L-carnitine (LC) on adipose tissue-derived mesenchymal stem cells (ADSCs), demonstrating that LC significantly increased telomerase activity, reduced cellular senescence, and altered the methylation status of CpG islands in the hTERT promoter, which regulates telomerase expression. These findings suggest LC could enhance

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June 26, 2025 No Comments