This 2013 review discusses the application of immunoadsorption (IAS) in treating connective tissue diseases (CTDs) such as systemic lupus erythematosus (SLE), systemic sclerosis, mixed connective tissue disease, dermatomyositis, and polymyositis. IAS is highlighted as a technique superior to plasma exchange due to its specificity and efficacy in removing pathogenic autoantibodies.
This case report describes the use of low-dose naltrexone (LDN) in a patient with systemic sclerosis experiencing severe pruritus unresponsive to conventional treatments. Administration of LDN at 4.5 mg nightly resulted in significant improvement in pruritus intensity and sleep quality within two weeks, with sustained benefits over several months. The
The study titled “Lipoic acid plays a role in scleroderma: insights obtained from scleroderma dermal fibroblasts” (Arthritis Research & Therapy, 2014, PMID: 25123250) explores the role of lipoic acid (LA) and its active metabolite, dihydrolipoic acid (DHLA), in systemic sclerosis (SSc), a disease characterized by fibrosis of the skin and
