Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality
This 2015 observational study published in Cell Reports (PMID: 26321641) examined how aging in Drosophila melanogaster (fruit flies) affects gut microbiota and intestinal barrier function. Researchers found that aging flies experienced a notable shift in gut microbiota composition, particularly an expansion of Gammaproteobacteria, which preceded and predicted intestinal barrier dysfunction.
June 26, 2025
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