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Tag: synaptogenesis

Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex

This study examined the antidepressant-like effects of cannabidiol (CBD) in rodent models, demonstrating that a single dose (7-30 mg/kg) produced rapid and sustained reductions in depressive-like behaviors. The effects were associated with increased expression of synaptic proteins (synaptophysin and PSD95), elevated brain-derived neurotrophic factor (BDNF) levels, and enhanced spine density

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June 26, 2025 No Comments

Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms

This review examines preclinical studies on cannabidiol (CBD) and its potential antidepressant effects, focusing on molecular mechanisms and interactions with neurotransmitter systems such as serotonergic, glutamatergic, and endocannabinoid pathways. CBD has been shown to enhance brain-derived neurotrophic factor (BDNF) signaling, promote synaptogenesis in the medial prefrontal cortex, and support neurogenesis

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June 26, 2025 No Comments

Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine

This systematic review explores the neurotrophic mechanisms underlying ketamine’s rapid and sustained antidepressant effects, particularly in treatment-resistant depression. Ketamine increases brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) in the medial prefrontal cortex and hippocampus, promoting synaptogenesis and neurogenesis. These actions reverse the neuronal atrophy commonly observed in

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June 26, 2025 No Comments