Well Referenced

Tag: symptom management

A Review of Alternative Treatment Options in Diabetic Polyneuropathy

This 2021 narrative review evaluates non-conventional treatment modalities for diabetic polyneuropathy (DPN), a common yet difficult-to-treat diabetes complication. It discusses pharmacologic and non-pharmacologic alternatives such as topical agents (capsaicin, lidocaine), nutritional supplements (alpha-lipoic acid, benfotiamine, acetyl-L-carnitine), and non-invasive modalities (acupuncture, electrical nerve stimulation). While several of these interventions demonstrated symptom

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June 26, 2025 No Comments

Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients During Chemo-/Radiotherapy and Aftercare: Results of a Retrospective, Multicentre, Epidemiological Cohort Study in Germany

This 2011 retrospective multicenter cohort study evaluated the safety and efficacy of intravenous vitamin C (IVC) administration in 125 women with breast cancer (UICC stages IIa–IIIb) during the first postoperative year. Fifty-three patients received 7.5 g IVC weekly alongside standard chemo-/radiotherapy, while 72 served as controls. The IVC group experienced

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June 26, 2025 No Comments

Impact of Intravenous Vitamin C Administration in Reducing Severity of Symptoms in Breast Cancer Patients During Treatment

This single-center, single-blind, randomized controlled trial conducted in Pakistan assessed the effects of intravenous vitamin C (IVC) on symptom severity in 350 breast cancer patients (stages IIA–IIIb) undergoing standard treatment. Participants were randomized to receive either 25g/week of IVC or placebo over four weeks. The IVC group showed statistically significant

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June 26, 2025 No Comments

Use of curcuminoids in a cohort of patients with oral lichen planus, an autoimmune disease

This randomized controlled trial investigated the use of curcuminoids, compounds derived from turmeric, in patients with oral lichen planus (OLP), a chronic autoimmune condition affecting the oral mucosa. The study found that curcuminoid treatment significantly reduced OLP symptoms compared to baseline, with no major adverse effects reported, indicating good tolerability.

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June 26, 2025 No Comments

Serum sTNF-R1, IL-6, and the development of fatigue in patients with gastrointestinal cancer undergoing chemoradiation therapy

This cohort study of 103 patients with gastrointestinal cancers undergoing concurrent chemoradiation therapy (CXRT) found that elevated levels of inflammatory markers—soluble tumor necrosis factor receptor 1 (sTNF-R1) and interleukin-6 (IL-6)—were significantly associated with worsening fatigue and other symptoms such as pain, drowsiness, and poor appetite during treatment. Both markers increased

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June 26, 2025 No Comments

Oral micronized progesterone for vasomotor symptoms–a placebo-controlled randomized trial in healthy postmenopausal women

This study investigated the effectiveness of oral micronized progesterone in alleviating vasomotor symptoms (VMS) such as hot flushes and night sweats in healthy postmenopausal women. The study, involving 133 women aged 44-62, found that those receiving 300 mg of oral micronized progesterone daily experienced significantly greater reductions in VMS compared

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June 26, 2025 No Comments