Well Referenced

Tag: survival

Viscum album L. extracts in breast and gynaecological cancers: a systematic review of clinical and preclinical research

This systematic review evaluated the clinical and preclinical effects of Viscum album L. (European mistletoe) extracts (VAE) in breast and gynaecological cancers. It included 19 randomized controlled trials (RCTs), 16 non-randomized controlled studies, and 11 single-arm cohort studies, encompassing over 9,900 patients. Findings indicated that VAE may improve quality of

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June 26, 2025 No Comments

Prospective Controlled Cohort Studies on Long-Term Therapy of Ovarian Cancer Patients with Mistletoe (Viscum album L.) Extracts Iscador

This 2007 study assessed the impact of long-term Iscador therapy on survival and psychosomatic self-regulation in ovarian cancer patients. It included two randomized matched-pair studies and two non-randomized matched-pair studies, comparing patients receiving Iscador with controls. Results indicated that Iscador therapy might prolong overall survival, particularly in patients with distant

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June 26, 2025 No Comments

Rising Incidence of Glioblastoma Multiforme in a Well-Defined Population

This 2020 epidemiological study analyzed glioblastoma multiforme (GBM) cases in Malta from 2008 to 2017. The incidence of GBM increased significantly from 0.73 to 4.49 per 100,000 people over the decade (p ≤ 0.001). Factors contributing to this rise may include an aging population, improved diagnostic techniques, and environmental exposures.

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June 26, 2025 No Comments

Statin Use is Associated with Improved Survival in Ovarian Cancer: A Retrospective Population-Based Study

This 2018 retrospective cohort study evaluated 5,416 ovarian cancer patients to investigate the association between statin use and overall survival. The study found that statin use correlated with a significant improvement in overall survival, particularly in patients with non-serous histologic subtypes. The proposed mechanisms include statins’ anti-inflammatory, anti-proliferative, and pro-apoptotic

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June 26, 2025 No Comments

The Influence of Isorel on Advanced Colorectal Cancer

This 2003 randomized, controlled clinical study investigated the impact of Isorel, a mistletoe extract (Viscum album L.), as an adjunct therapy in patients with advanced colorectal cancer (Dukes C and D stages). Participants were allocated into three groups: surgery alone, surgery plus standard 5-fluorouracil (5-FU) chemotherapy, and surgery plus chemotherapy

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June 26, 2025 No Comments

Naltrexone’s Impact on Cancer Progression and Mortality: A Systematic Review of Studies in Humans, Animal Models, and Cell Cultures

This 2021 systematic review evaluates the effects of naltrexone (NTX), including low-dose naltrexone (LDN), on cancer progression and mortality across human, animal, and cell culture studies. Findings indicate that LDN (3–5 mg/day) may inhibit tumor growth and metastasis, potentially by modulating opioid receptors and immune responses. Conversely, high-dose or continuous

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June 26, 2025 No Comments

CA125: A superior prognostic biomarker for colorectal cancer compared to CEA, CA19-9 or CA242

This 2020 study assessed the prognostic value of serum CA125 in colorectal cancer (CRC) patients compared to established markers—CEA, CA19-9, and CA242. Researchers analyzed preoperative biomarker levels and their correlations with overall survival (OS) and disease-free survival (DFS). CA125 showed the strongest predictive power for advanced tumor stage, lymph node

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June 26, 2025 No Comments

Evidence on Statins, Omega-3, and Prostate Cancer: A Narrative Review

This 2022 narrative review examines the associations between statin use, omega-3 fatty acid intake, and prostate cancer (PCa) risk and progression. Statins have been linked to a reduced incidence of advanced PCa and may decrease the risk of biochemical recurrence (BCR) post-treatment. However, their impact on BCR and PCa progression

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June 26, 2025 No Comments