This 2023 review examines the “obesity paradox,” where overweight and obese individuals with established cardiovascular disease (CVD) often exhibit better survival rates than their leaner counterparts. The authors highlight that cardiorespiratory fitness (CRF) plays a pivotal role in this phenomenon, suggesting that higher CRF levels may mitigate the adverse effects
A systematic review published in the Cochrane Database of Systematic Reviews (2002) compared the effectiveness of early versus deferred androgen suppression therapy in men with advanced prostate cancer. The review, which analyzed data from 2,167 patients, found that early androgen suppression resulted in modest improvements in overall survival (18% vs.
A review published in Lancet Oncology (2008) examined treatments for locally advanced prostate cancer, including prostatectomy, external beam radiation therapy (EBRT) combined with gonadorelin agonists, and androgen suppression. The study found that prostatectomy has a 2% to 16% cancer-specific mortality rate over five years, but with significant side effects like
