This 2019 comprehensive review discusses heterotopic ossification (HO), the pathological formation of bone in soft tissues. HO is often triggered by trauma, surgery, burns, or neurological injuries. The review covers clinical features, radiographic and histopathologic diagnosis, and treatment options, including NSAIDs, radiation therapy, and surgical excision. It also explores the
In this 2010 prospective study published in The Journals of Gerontology: Series A, Bautmans et al. investigated the interplay between postoperative inflammation, age, muscle function, and fatigue. Sixty-six patients aged 24–91 undergoing elective abdominal surgery were assessed preoperatively and on postoperative days 2 and 4. Measurements included grip strength, muscle
This 2013 randomized controlled trial by Rodrigo et al., published in Frontiers in Cardiovascular Medicine, investigated the efficacy of antioxidant reinforcement in preventing postoperative atrial fibrillation (POAF) in patients undergoing cardiac surgery. The study enrolled 120 patients scheduled for coronary artery bypass grafting (CABG), randomly assigning them to receive either
This 2015 review by Zakkar et al., published in Pharmacology & Therapeutics, explores the mechanisms by which inflammation and oxidative stress contribute to postoperative atrial fibrillation (POAF) following cardiac surgery. The authors discuss how surgical procedures trigger systemic inflammatory responses and oxidative stress, leading to atrial structural and electrical remodeling.
This study evaluates the use of Viscum album extract (Isorel) as an adjuvant cancer biotherapy, reporting its benefits in combination with conventional treatments like surgery and radiotherapy. The study found that Isorel helped prevent tumor recurrence in 47% of patients, led to tumor regression in 38%, and showed no health
This randomized controlled trial evaluated the long-term outcomes of monitoring, surgery, or radiotherapy in patients with localized prostate cancer. Over a 10-year period, the study found no significant differences in prostate cancer-specific mortality between the three treatment groups. However, surgery and radiotherapy were associated with higher rates of erectile dysfunction
A cohort study published in Lancet Oncology (2008) examined the role of tumor hypoxia and angiogenesis markers in predicting the outcome of radical treatments for localized prostate cancer. The study found that high expression levels of VEGF and HIF-1α were linked to shorter biochemical failure-free survival in both radiotherapy and
