This 2013 case-control study by Sivaranjani et al. assessed oxidative stress markers in 25 patients with atopic dermatitis (AD) compared to 25 healthy controls. The study found significantly elevated levels of malondialdehyde (MDA), a marker of lipid peroxidation, in AD patients. Concurrently, there was a marked reduction in both enzymatic
This case-control study assessed oxidative stress and antioxidant enzyme levels in 60 patients with age-related cataracts compared to 60 healthy controls. Results showed significantly reduced serum activities of key antioxidant enzymes—superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px)—in cataract patients. Concurrently, levels of oxidative stress markers such as malondialdehyde
This 2014 review examines the role of dietary antioxidants in the aging process. It highlights that while oxygen is essential for aerobic organisms, it also leads to the continuous generation of reactive oxygen species (ROS), which are implicated in aging. The body’s antioxidant defense system, comprising enzymes like superoxide dismutase
This study evaluated the anti-inflammatory effects of ozonated water in a mouse model of acute inflammation induced by lipopolysaccharide (LPS). The results showed that intraperitoneal injection of ozonated water significantly decreased tumor necrosis factor-α (TNF-α) levels and increased superoxide dismutase (SOD) activity, suggesting its potential as an anti-inflammatory agent. Ozonated
This observational study examined the effects of phosphatidylcholine (PC) with different fatty acid compositions on cognitive function and oxidative stress in mice with scopolamine-induced cognitive decline. Mice supplemented with PC rich in EPA (sea cucumber PC) and DHA (squid PC) showed significant improvements in learning and memory performance, reduced acetylcholinesterase
This in vitro study investigated the effects of malondialdehyde (MDA), a byproduct of lipid peroxidation, on mitochondrial function in rat brain mitochondria. MDA exposure led to a dose-dependent reduction in mitochondrial membrane potential, inhibited complex I- and II-linked respiration, and suppressed the activity of key enzymes like NADH dehydrogenase, succinate
