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Tag: Sulforaphane

Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder

This 36-week Phase II randomized, double-blind, placebo-controlled trial evaluated the safety, tolerability, and efficacy of sulforaphane (SF) in 57 children aged 3–12 years with autism spectrum disorder (ASD). Participants received either SF (derived from broccoli seed and sprout extract tablets containing glucoraphanin and active myrosinase, yielding approximately 15 µmol SF

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June 26, 2025 No Comments

Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy

This review article explores the potential of phytochemicals in targeting breast cancer stem cells (BCSCs) and associated signaling pathways. It discusses various plant-derived compounds, such as curcumin, genistein, resveratrol, and sulforaphane, highlighting their mechanisms in inhibiting BCSC proliferation, inducing apoptosis, and modulating key pathways like Wnt/β-catenin, Notch, Hedgehog, and PI3K/Akt/mTOR.

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June 26, 2025 No Comments

Sulforaphane – role in aging and neurodegeneration

This 2019 review explores sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables, highlighting its potential in mitigating aging and neurodegenerative processes. SFN activates the Nrf2 pathway, enhancing antioxidant responses, and inhibits NF-κB, reducing inflammation. It also exhibits epigenetic effects by inhibiting histone deacetylases and DNA methyltransferases, and modulates mitochondrial dynamics.

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June 26, 2025 No Comments