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Tag: sorafenib

Therapeutic Effects of Artesunate in Hepatocellular Carcinoma: Repurposing an Ancient Antimalarial Agent

This preclinical study investigated the anticancer properties of artesunate, a semisynthetic artemisinin derivative, in hepatocellular carcinoma (HCC). Artesunate significantly inhibited cell viability and induced caspase-3-mediated apoptosis in HCC cell lines (HepG2, BWTG3), with more pronounced effects under hypoxic conditions. It also suppressed angiogenic markers VEGF and placental growth factor, leading

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June 26, 2025 No Comments

Comparative efficacy of novel combination strategies for unresectable hepatocellular carcinoma: A network metanalysis of phase III trials

This network meta-analysis synthesized data from nine phase III randomized controlled trials to assess the relative efficacy of various first-line systemic therapies for unresectable hepatocellular carcinoma (HCC). The study found that combinations of immune checkpoint inhibitors (ICIs) and anti-VEGF agents, particularly atezolizumab plus bevacizumab, demonstrated the most favorable outcomes in

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June 26, 2025 No Comments