The relative roles of continuous growth hormone-releasing hormone (GHRH(1-29)NH2) and intermittent somatostatin(1-14)(SS) in GH pulse generation: studies in normal and post-cranial irradiated individuals
This randomized controlled trial (PMID: 10594518) evaluated how continuous GHRH(1-29)NH2 infusion and intermittent somatostatin withdrawal influenced GH pulse generation in n=12 long-term survivors and n=6 short-term survivors of childhood brain tumors post-cranial irradiation, compared to n=9 and n=6 healthy matched controls. In healthy adults, pulsatile GH secretion persisted under GHRH
June 26, 2025
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