Well Referenced

Tag: Skin aging

A Prospective, Randomized, Double-Blind, Vehicle-Controlled Study Evaluating the Efficacy, Safety, and Patient Satisfaction of Tretinoin 0.05% Lotion for Chest Rejuvenation

This 2022 randomized, double-blind, vehicle-controlled study assessed the efficacy, safety, and patient satisfaction of tretinoin 0.05% lotion for chest rejuvenation in 29 patients aged 37–66 years with Fitzpatrick skin types II–IV. Over 180 days, both the tretinoin and vehicle groups demonstrated 30–40% improvement in photodamage, as evaluated by blinded assessors.

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June 26, 2025 No Comments

Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials

This systematic review evaluates the efficacy and safety of topical tretinoin in treating photoaging by analyzing seven randomized controlled trials. The studies included predominantly female participants and utilized tretinoin concentrations ranging from 0.025% to 5%, with treatment durations between 3 to 24 months. Results consistently demonstrated significant improvements in clinical

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June 26, 2025 No Comments

An Open Label Clinical Trial to Evaluate the Efficacy and Tolerance of a Retinol and Vitamin C Facial Regimen in Women With Mild-to-Moderate Hyperpigmentation and Photodamaged Facial Skin

This 2016 open-label, single-center clinical trial evaluated the efficacy and tolerability of a dual-product regimen comprising a 0.5% encapsulated retinol treatment and a moisturizer containing 30% tetrahexyldecyl ascorbate (vitamin C), along with vitamin E and coenzyme Q10, in 44 women aged 35–60 with mild-to-moderate facial hyperpigmentation and photodamage over 12

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June 26, 2025 No Comments

Effects and Side-Effects of 2% Progesterone Cream on the Skin of Peri- and Postmenopausal Women: Results from a Double-Blind, Vehicle-Controlled, Randomized Study

This 2005 randomized, double-blind, vehicle-controlled study evaluated the effects of 2% topical progesterone cream on skin aging in 40 peri- and postmenopausal women over 16 weeks. The treatment group demonstrated significant improvements in skin elasticity and firmness, with a 29.1% reduction in wrinkle count and a 9.72% decrease in wrinkle

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June 26, 2025 No Comments

Treatment of Skin Aging with Topical Estrogens

This 1998 study evaluated the effects of topical estradiol (0.01%) and estriol (0.3%) creams on skin aging in 59 perimenopausal women over six months. Both treatments significantly improved skin elasticity, firmness, and moisture, with reductions in wrinkle depth and pore size ranging from 61% to 100%. Immunohistochemical analysis revealed increased

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June 26, 2025 No Comments

Estrogen-Deficient Skin: The Role of Topical Therapy

This 2019 review discusses the impact of estrogen deficiency on skin aging in postmenopausal women, highlighting symptoms such as dryness, atrophy, fine wrinkling, and poor wound healing. The article evaluates topical treatments, including estrogen creams and soy-derived isoflavones like genistein, which interact with estrogen receptors in the skin. Clinical studies

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June 26, 2025 No Comments

Anti-Aging Potentials of Methylene Blue for Human Skin Longevity

This 2017 study evaluated methylene blue (MB) as a potential anti-aging agent for human skin. MB demonstrated potent reactive oxygen species (ROS) scavenging in cultured human skin fibroblasts from both healthy donors and progeria patients. Compared to other antioxidants like N-Acetyl-L-Cysteine (NAC), MitoQ, and MitoTEMPO, MB more effectively stimulated fibroblast

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June 26, 2025 No Comments

The Aesthetic Unit Principle of Facial Aging

This 2015 study by Tan et al. investigated how the separation of facial aesthetic units (AUs) affects perceived youthfulness. In youth, facial AUs blend seamlessly, but with aging, they become more distinct due to changes in skin thickness, subcutaneous tissue composition, skeletal contours, and ligament positioning. The study presented photographs

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June 26, 2025 No Comments

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

This 2019 systematic review analyzed 11 randomized, placebo-controlled trials involving 805 participants to assess the effects of oral collagen supplementation on skin health. The studies primarily utilized collagen hydrolysate (2.5–10 g/day over 8–24 weeks) and collagen tripeptides (3 g/day for 4–12 weeks). Findings indicated significant improvements in skin elasticity, hydration,

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June 26, 2025 No Comments