Well Referenced

Tag: skeletal muscle

MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism

This 2016 study introduces MOTS-c, a mitochondrial-derived peptide encoded within the 12S rRNA gene, highlighting its role in regulating metabolic homeostasis. MOTS-c enhances insulin sensitivity, promotes glucose utilization, and prevents high-fat diet-induced obesity and insulin resistance in mice. It primarily targets skeletal muscle but also influences adipose tissue, acting through

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June 26, 2025 No Comments

Striated, Smooth, and Heart Muscle

This 2022 review article explores the therapeutic potential of the stable gastric pentadecapeptide BPC 157 in the regeneration and functional recovery of striated, smooth, and cardiac muscles. BPC 157 demonstrates cytoprotective properties that facilitate healing in various muscle injuries, including myotendinous junction disruptions, by promoting angiogenesis, fibroblast proliferation, and collagen

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June 26, 2025 No Comments

NAD⁺: A Big Player in Cardiac and Skeletal Muscle Remodeling and Aging

This review highlights the pivotal role of NAD⁺ in cardiac and skeletal muscle health, emphasizing its antioxidant and anti-aging properties. Replenishment of NAD⁺ has been shown to ameliorate muscle dystrophy in mice by enhancing mitochondrial function and extending lifespan. Additionally, NAD⁺ supplementation improves cardiac relaxation in heart failure models by

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June 26, 2025 No Comments

The Effects of BCAAs on Insulin Resistance in Athletes

This review article, The Effects of BCAAs on Insulin Resistance in Athletes (Journal of Nutritional Science and Vitaminology, 2019;65(5):383-389, DOI: 10.3177/jnsv.65.383), explores how branched-chain amino acids (BCAAs) affect insulin resistance in different tissues and under varying conditions. It explains that BCAA catabolic intermediates, such as 3-hydroxy-isobutyrate from valine, promote lipid

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June 26, 2025 No Comments

The influence of estrogen on skeletal muscle: sex matters

The article “The influence of estrogen on skeletal muscle: sex matters” reviews the role of estrogen in skeletal muscle function and its sex-specific effects. It discusses how estrogen can improve muscle contractile properties, reduce muscle damage after exercise, and modulate inflammation. Animal studies suggest estrogen has protective effects on muscle

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June 26, 2025 No Comments

Exercise-induced muscle damage and the potential protective role of estrogen

This 2002 review article examines exercise-induced muscle damage (EIMD) and the potential protective role of estrogen in muscle repair. EIMD, often caused by unaccustomed or strenuous physical activity, leads to muscle soreness and inflammation. Estrogen is hypothesized to have antioxidant and membrane-stabilizing properties that may reduce muscle damage, as observed

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June 26, 2025 No Comments