Well Referenced

Tag: Sirt3

It Takes Two to Tango: NAD⁺ and Sirtuins in Aging/Longevity Control

This 2016 review elucidates the synergistic relationship between NAD⁺ and sirtuins in regulating aging and longevity. It details how NAD⁺-dependent sirtuins, particularly SIRT1 and SIRT3, influence metabolic pathways, mitochondrial function, and stress responses. The paper discusses how declining NAD⁺ levels with age impair sirtuin activity, leading to disrupted nuclear-mitochondrial communication

Read More »
June 26, 2025 No Comments

The Sirtuins, Oxidative Stress and Aging: An Emerging Link

This review explores the role of sirtuins, a family of NAD⁺-dependent deacetylases, in modulating oxidative stress and aging. Sirtuins, particularly SIRT1 and SIRT3, enhance cellular resistance to oxidative damage by deacetylating key transcription factors and enzymes involved in antioxidant defense, such as FOXO proteins and SOD2. Caloric restriction activates sirtuins,

Read More »
June 26, 2025 No Comments

Maintaining good hearing: calorie restriction, Sirt3, and glutathione

This review examines how calorie restriction (CR) can slow the progression of age-related hearing loss (AHL), a common aging condition linked to the degeneration of sensory hair cells, spiral ganglion neurons, and the stria vascularis in the cochlea. The study highlights mitochondrial Sirt3, a sirtuin protein, as a critical mediator

Read More »
June 26, 2025 No Comments