Well Referenced

Tag: side effect profile

Efficacy and Safety of Oral Magnesium Supplementation in the Treatment of Depression in the Elderly With Type 2 Diabetes: A Randomized, Equivalent Trial

This 2008 randomized controlled trial evaluated the effectiveness of oral magnesium supplementation versus imipramine in treating depression among elderly patients with type 2 diabetes. The study found that magnesium was equally effective as imipramine in improving depression scores, while offering a more favorable side effect profile. Magnesium’s role in neurotransmitter

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June 26, 2025 No Comments

Methylene Blue Analogues with Marginal Monoamine Oxidase Inhibition Retain Antidepressant-like Activity

This study investigated five newly synthesized methylene blue (MB) analogues with low monoamine oxidase A (MAO-A) inhibitory activity to assess their antidepressant-like effects. In rats, these analogues exhibited significant antidepressant effects in the forced swim test (FST), similar to imipramine and MB, without affecting locomotor activity. Their IC₅₀ values for

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June 26, 2025 No Comments