This review explores the complex relationship between testosterone levels and metabolic syndrome (MetS) in men. Low total testosterone (TT) and sex hormone-binding globulin (SHBG) levels are commonly observed in men with MetS, primarily due to hyperinsulinemia and increased inflammatory cytokines associated with obesity. Low SHBG levels have been identified as
This review article examines the multifaceted effects of obesity on male reproductive health. Obesity is associated with decreased testosterone levels, sexual dysfunction, and impaired sperm parameters. Mechanisms include reduced hypothalamic and pituitary secretory function, increased estrogen production due to aromatization in adipose tissue, and decreased sex hormone-binding globulin (SHBG) levels.
This 1998 study evaluated the impact of vertical banded gastroplasty (VBG) on sex hormone levels in 57 morbidly obese patients (19 men and 38 premenopausal women) over a 12-month period. In men, significant hormonal changes included decreased estradiol and increased levels of follicle-stimulating hormone (FSH), total testosterone, and sex hormone-binding
This 2008 collaborative meta-analysis by the Endogenous Hormones and Prostate Cancer Collaborative Group pooled data from 18 prospective studies, encompassing 3,886 men with incident prostate cancer and 6,438 controls, to assess the relationship between circulating endogenous sex hormones and prostate cancer risk. The analysis found no significant associations between prostate
This exploratory, prospective, non-controlled observational study assessed the efficacy of Libicare®, a multi-ingredient food supplement, in improving sexual function among 29 postmenopausal women aged 45–65 with low sexual desire (FSFI < 25.83). Participants consumed two tablets daily for two months. Libicare® contains extracts of Trigonella foenum-graecum, Turnera diffusa, Tribulus terrestris,
In the study “Women with low libido: correlation of decreased androgen levels with female sexual function index” (Int J Impot Res, 2005, PMID: 15592425), researchers investigated the relationship between androgen levels and sexual function in women with low libido compared to age-matched controls. The study included 20 premenopausal and 20
