This 2018 review by Snyder et al. summarizes findings from the Testosterone Trials (TTrials), a coordinated set of seven placebo-controlled, double-blind trials involving 788 men aged 65 and older with low testosterone levels. The trials assessed the effects of testosterone therapy on various health domains. Key findings include: increased sexual
This 2016 study analyzed sexual function outcomes in 118 men with localized prostate cancer treated with high-intensity focused ultrasound (HIFU) across three prospective trials. Patients had PSA ≤15 ng/ml, Gleason score ≤4+3, and stage ≤T3aN0M0. The International Index of Erectile Function (IIEF-15) scores declined significantly at 1 month post-treatment but
This 2020 prospective cohort study evaluated five-year patient-reported outcomes in 2,005 men with localized prostate cancer treated with active surveillance, prostatectomy, brachytherapy, or external beam radiation therapy (EBRT), with or without androgen deprivation therapy (ADT). Results showed that prostatectomy led to greater declines in urinary continence and sexual function, particularly
This 2016 double-blind, randomized, placebo-controlled trial investigated the effects of Testofen, a standardized Trigonella foenum-graecum (fenugreek) seed extract, on symptoms of androgen deficiency, sexual function, and serum testosterone levels in 120 healthy men aged 43–70. Participants received 600 mg/day of Testofen or placebo for 12 weeks. The primary outcome, the
This 2013 review discusses the clinical use of androgen therapy in women, particularly for those experiencing hypoactive sexual desire disorder (HSDD). It highlights the role of androgens in sexual function, behavior, and cognition, noting that adrenal androgens may influence sexual symptoms and cognitive function in postmenopausal women. The article emphasizes
This 2009 review evaluates the benefits and risks of testosterone replacement therapy (TRT) in men with hypogonadism. TRT has been shown to improve libido, sexual function, bone density, muscle mass, body composition, mood, erythropoiesis, cognition, quality of life, and cardiovascular health. However, concerns remain regarding potential adverse effects, including prostate
This exploratory, prospective, non-controlled observational study assessed the efficacy of Libicare®, a multi-ingredient food supplement, in improving sexual function among 29 postmenopausal women aged 45–65 with low sexual desire (FSFI < 25.83). Participants consumed two tablets daily for two months. Libicare® contains extracts of Trigonella foenum-graecum, Turnera diffusa, Tribulus terrestris,
This systematic review analyzed 10 double-blind, randomized, placebo-controlled trials to assess the efficacy of various ginseng preparations, including Korean Red Ginseng (KRG) and American ginseng, in managing menopausal symptoms. The findings indicated that ginseng may positively influence sexual function and reduce total hot flash scores, particularly with KRG. However, the
This double-blind, randomized, placebo-controlled study evaluated the effects of a standardized Trigonella foenum-graecum (fenugreek) seed extract (Libifem) on sex hormones and sexual function in 80 healthy menstruating women aged 20–49 years with self-reported low sexual desire. Participants received 600 mg/day of Libifem or placebo over two menstrual cycles. Outcomes included
This 2013 randomized, double-blind, placebo-controlled trial assessed the efficacy and safety of standardized Korean ginseng berry (SKGB) extract in 119 men with mild-to-moderate erectile dysfunction (ED). Participants received 1,400 mg/day of SKGB extract (350 mg per tablet, 4 tablets daily) for 8 weeks. The primary outcome, International Index of Erectile
