This 1976 review article by J. Cohen examines the impact of oral contraceptives on various aspects of women’s sexual behavior. The study found that 34–54% of women reported an increase in the frequency of sexual relations, while 32% experienced improved orgasm. However, 5–6% of women in rigorous studies reported frigidity,
This 2002 randomized, double-blind, placebo-controlled trial assessed the effects of 3,000 mg/day sustained-release ascorbic acid (vitamin C) on sexual behavior and mood in 81 healthy young adults over 14 days. Participants recorded daily instances of penile-vaginal intercourse (PVI), noncoital partner sex, and masturbation, and completed the Beck Depression Inventory pre-
This preclinical study examines the effects of melanocortins, particularly bremelanotide, on male sexual dysfunction, specifically focusing on its ability to promote erections and enhance sexual activity behaviors. The results suggest that bremelanotide, a melanocortin receptor agonist, may offer a promising treatment for sexual dysfunction by interacting with the central nervous
This preclinical study examined the effects of bremelanotide, an α-MSH analogue, on sexual desire in female rats, focusing on its impact on specific brain regions. Results showed that bremelanotide significantly increased solicitation behaviors, an indicator of heightened sexual desire, without affecting pacing or lordosis. These effects were linked to activation
