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Tag: sertraline

Fluoxetine versus sertraline and paroxetine in major depressive disorder: changes in weight with long-term treatment

This 2002 randomized, double-blind study evaluated weight changes over 26–32 weeks in 284 patients with major depressive disorder treated with fluoxetine, sertraline, or paroxetine. Paroxetine-treated patients experienced a significant average weight gain of 3.6%, with 25.5% gaining more than 7% of their baseline weight. In contrast, fluoxetine-treated patients had a

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June 26, 2025 No Comments

An easily overlooked cause of toxic encephalopathy: methylene blue in a patient on an SSRI

This case report highlights a serious drug interaction between methylene blue (MB) and selective serotonin reuptake inhibitors (SSRIs), leading to toxic encephalopathy and serotonin syndrome. A patient on sertraline underwent surgery where MB was administered, resulting in postoperative neurological symptoms, including altered mental status. MB inhibits monoamine oxidase A (MAO-A),

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June 26, 2025 No Comments