Well Referenced

Tag: serotonin syndrome

An easily overlooked cause of toxic encephalopathy: methylene blue in a patient on an SSRI

This case report highlights a serious drug interaction between methylene blue (MB) and selective serotonin reuptake inhibitors (SSRIs), leading to toxic encephalopathy and serotonin syndrome. A patient on sertraline underwent surgery where MB was administered, resulting in postoperative neurological symptoms, including altered mental status. MB inhibits monoamine oxidase A (MAO-A),

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June 26, 2025 No Comments

Methylene blue and its analogues as antidepressant compounds

This review explores the antidepressant and anxiolytic properties of methylene blue (MB) and its analogues. MB exerts its effects through mechanisms such as monoamine oxidase A (MAO-A) inhibition, which increases neurotransmitter levels, and modulation of nitric oxide pathways. These actions suggest MB’s potential as a therapeutic agent for treating mood

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June 26, 2025 No Comments