This study investigates the antidepressant-like effects of cannabidiol (CBD) in mice, highlighting its role in serotonin modulation. Administering 10 mg/kg of CBD induced significant antidepressant effects in the forced swim test (FST), comparable to fluoxetine (10 mg/kg) and desipramine (5 mg/kg). Lower doses of CBD (7 mg/kg) combined with sub-effective
This study examines the antidepressant-like effects of cannabidiol (CBD) in mice, demonstrating that a dose of 30 mg/kg significantly reduced immobility in the forced swimming test, an effect comparable to the standard antidepressant imipramine. The study suggests that CBD’s effects are mediated through 5-HT1A receptor activation, as they were blocked
This review examines preclinical studies on cannabidiol (CBD) and its potential antidepressant effects, focusing on molecular mechanisms and interactions with neurotransmitter systems such as serotonergic, glutamatergic, and endocannabinoid pathways. CBD has been shown to enhance brain-derived neurotrophic factor (BDNF) signaling, promote synaptogenesis in the medial prefrontal cortex, and support neurogenesis
