Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism
This 2019 review evaluates enclomiphene citrate, the trans-isomer of clomiphene citrate, as a treatment for secondary hypogonadism in men desiring fertility preservation. Enclomiphene acts as a selective estrogen receptor modulator (SERM), antagonizing estrogen receptors in the hypothalamus and pituitary gland, thereby stimulating the hypothalamic-pituitary-gonadal axis to increase endogenous luteinizing hormone
June 26, 2025
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