Well Referenced

Tag: SARS-CoV-2

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

This 2020 study by Yao et al. evaluated the antiviral efficacy of hydroxychloroquine (HCQ) against SARS-CoV-2 in vitro and proposed optimized dosing regimens using physiologically based pharmacokinetic (PBPK) modeling. HCQ demonstrated greater potency than chloroquine, with an EC50 of 0.72 μM compared to 5.47 μM. The PBPK model suggested that

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June 26, 2025 No Comments

Ozone therapy in COVID-19: A narrative review

This 2021 narrative review titled “Ozone therapy in COVID-19: A narrative review” (Virus Research, DOI: [10.1016/j.virusres.2020.198207*) assessed the potential role of ozone therapy as an adjunctive treatment for COVID-19. The authors discussed how ozone’s antiviral, anti-inflammatory, immunomodulatory, and oxygenation-enhancing properties could theoretically target key pathophysiological processes like cytokine storms and

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June 26, 2025 No Comments

Serum interleukin-6 is an indicator for severity in 901 patients with SARS-CoV-2 infection: a cohort study

This cohort study of 901 patients with confirmed COVID-19 found that elevated serum interleukin-6 (IL-6) levels strongly correlate with disease severity and mortality. Critical cases had significantly higher IL-6 concentrations (median 21.55 pg/ml) than severe or common cases (P < 0.001), and IL-6 levels above 37.65 pg/ml predicted in-hospital mortality

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June 26, 2025 No Comments