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Tag: Salinomycin

Salinomycin: A new paradigm in cancer therapy

This comprehensive review discusses salinomycin, a polyether antibiotic identified as a potent agent against cancer stem cells (CSCs) and multidrug-resistant tumors. Salinomycin functions by disrupting key oncogenic signaling pathways including Wnt/β-catenin, Notch, Hedgehog, and Akt, reducing CSC viability and enhancing sensitivity to standard chemotherapeutics. Mechanistically, it induces apoptosis, autophagy, and

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June 26, 2025 No Comments

Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications

This article explores the anticancer effects of salinomycin, a compound originally used as an antibiotic, in breast cancer. The study highlights salinomycin’s ability to target breast cancer stem cells, inhibit tumor growth, and induce apoptosis through multiple mechanisms, including oxidative stress and mitochondrial dysfunction. The article discusses potential clinical applications,

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June 26, 2025 No Comments