Well Referenced

Tag: safety

Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium in Patients with Age-Related Macular Degeneration and Stargardt’s Macular Dystrophy: Follow-Up of Two Open-Label Phase 1/2 Studies

This study reports on two open-label Phase 1/2 trials assessing the safety and tolerability of subretinal transplantation of human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) in nine patients with atrophic age-related macular degeneration (AMD) and nine with Stargardt’s macular dystrophy. Patients received varying doses (50,000 to 150,000 cells) and

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June 26, 2025 No Comments

Intra-articular Injections of Expanded Mesenchymal Stem Cells with and without Addition of Platelet-Rich Plasma Are Safe and Effective for Knee Osteoarthritis

This randomized controlled trial evaluated the safety and efficacy of intra-articular injections of autologous expanded mesenchymal stem cells (MSCs) alone or combined with platelet-rich plasma (PRP) in 18 patients with symptomatic knee osteoarthritis (OA). Participants were randomized to receive either MSCs alone or MSCs plus PRP. Both groups demonstrated significant

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June 26, 2025 No Comments

Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial

This Phase I/II randomized controlled trial assessed the safety and efficacy of intra-articular injections of umbilical cord-derived mesenchymal stromal cells (UC-MSCs) in patients with symptomatic knee osteoarthritis (OA). Participants were randomized into three groups: hyaluronic acid (HA) injections at baseline and 6 months (n=8), a single UC-MSC dose at baseline

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June 26, 2025 No Comments

St. John’s wort: a new alternative for depression?

This 1999 review article evaluates the efficacy, safety, and potential drug interactions of St. John’s wort (Hypericum perforatum) as an alternative treatment for depression. Analyzing nine clinical trials, including four large-scale studies, the review found that St. John’s wort was more effective than placebo and comparable to standard antidepressants in

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June 26, 2025 No Comments

Effects of 15-d Repeated Consumption of Hoodia gordonii Purified Extract on Safety, Ad Libitum Energy Intake, and Body Weight in Healthy, Overweight Women: A Randomized Controlled Trial

This 15-day randomized, double-blind, placebo-controlled trial evaluated the safety and efficacy of Hoodia gordonii purified extract (HgPE) in 49 healthy overweight women. Participants consumed 2 servings per day of 1110 mg HgPE or placebo in a yogurt drink. The HgPE group experienced adverse effects such as nausea, vomiting, and skin

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June 26, 2025 No Comments

Weight Reduction and Maintenance with IQP-PV-101: A 12-Week Randomized Controlled Study with a 24-Week Open Label Period

This study assessed the efficacy and safety of IQP-PV-101, a proprietary extract of Phaseolus vulgaris, in weight management. In the 12-week double-blind, placebo-controlled weight loss phase, participants adhering to a mildly hypocaloric diet received either IQP-PV-101 or placebo. The IQP-PV-101 group experienced a significant mean weight loss of 2.91 ±

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June 26, 2025 No Comments

To Evaluate Efficacy and Safety of Caralluma Fimbriata in Overweight and Obese Patients: A Randomized, Single Blinded, Placebo Control Trial

This 12-week randomized, single-blind, placebo-controlled trial assessed the efficacy and safety of Caralluma fimbriata extract (CFE) in 89 overweight and obese individuals. Participants received either 1 g/day of CFE or a matching placebo. Both groups exhibited numerical reductions in weight, BMI, waist and hip circumference, and waist-hip ratio; however, these

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June 26, 2025 No Comments

The Effect of Vitamin C (Ascorbic Acid) in the Treatment of Patients with Cancer: A Systematic Review

This 2019 systematic review assessed the efficacy and safety of vitamin C supplementation in cancer treatment. Nineteen trials were included, with only four employing randomization. The studies varied widely in design, patient populations, and intervention protocols. Overall, the evidence did not demonstrate a clinically significant benefit of vitamin C on

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June 26, 2025 No Comments