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Tag: reperfusion injury

Α‑lipoic acid protects against cerebral ischemia/reperfusion-induced injury in rats

This 2015 study published in Molecular Medicine Reports (DOI: 10.3892/mmr.2015.3170, PMID: 25572614) explored the neuroprotective effects of alpha-lipoic acid (ALA) in a rat model of cerebral ischemia/reperfusion (I/R) injury. The results showed that ALA treatment significantly reduced infarct size, improved neurological deficits, and decreased oxidative stress markers, including malondialdehyde (MDA)

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June 26, 2025 No Comments

Progesterone receptor replenishment in T47D human breast cancer cells. Roles of protein synthesis and hormone metabolism

This study examines the neuroprotective effects of progesterone following cerebral ischemia and reperfusion injury in rats. The findings show that progesterone administration significantly preserves mitochondrial function and reduces neuronal apoptosis in the brain regions affected by ischemia. These results suggest that progesterone may offer therapeutic benefits for mitigating ischemic brain

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June 26, 2025 No Comments