Allopregnanolone affects sleep in a benzodiazepine-like fashion
This 1997 study investigated the effects of allopregnanolone, a neuroactive steroid derived from progesterone, on sleep patterns in rats. The findings revealed that allopregnanolone enhances high-frequency EEG activity (≥17 Hz) during REM sleep, particularly within the first hour post-injection, mirroring the effects of benzodiazepines. The study suggests that allopregnanolone modulates
June 26, 2025
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