Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group
This randomized controlled trial evaluated the effectiveness of daily subcutaneous administration of growth hormone-releasing hormone (GHRH(1-29)) in 110 children with growth hormone deficiency. Over a 12-month period, the treatment significantly increased height velocity, with an average increase to 8.0 cm/year at 6 months and 7.2 cm/year at 12 months. At