Metformin directly inhibits ghrelin secretion through AMP-activated protein kinase in rat primary gastric cells
This 2013 study investigated the direct effects of metformin on ghrelin secretion in rat primary gastric cells. The researchers found that metformin significantly reduced ghrelin secretion and proghrelin mRNA levels. These inhibitory effects were mediated through the activation of AMP-activated protein kinase (AMPK), as co-incubation with the AMPK inhibitor compound
June 26, 2025
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