Well Referenced

Tag: radiation therapy

The Comparative Oncologic Effectiveness of Available Management Strategies for Clinically Localized Prostate Cancer

This 2017 review examines the comparative effectiveness of various treatment modalities for clinically localized prostate cancer, focusing on oncologic control. It evaluates radical prostatectomy, radiation therapy, and observation strategies, highlighting the trade-offs between treatment benefits and potential harms. The review also discusses emerging therapies such as cryotherapy and high-intensity focused

Read More »
June 26, 2025 No Comments

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer

This 2015 study investigated the effects of pharmacological doses of ascorbate (vitamin C) on pancreatic cancer cells in combination with ionizing radiation. The researchers found that pharmacological ascorbate enhances the cytotoxic effects of radiation, leading to decreased cell viability and clonogenic survival in various pancreatic cancer cell lines, while sparing

Read More »
June 26, 2025 No Comments

Novel Radiation Therapy Approaches for Breast Cancer Treatment

This 2020 review highlights advancements in radiation therapy for breast cancer, focusing on techniques that enhance precision and reduce toxicity. Partial Breast Irradiation (PBI) has been validated in randomized trials as effective for selected patients, offering reduced treatment times and side effects compared to Whole Breast Irradiation (WBI). Intraoperative Radiation

Read More »
June 26, 2025 No Comments

Emerging Perspectives on the Antiparasitic Mebendazole as a Repurposed Drug for the Treatment of Brain Cancers

This 2023 review highlights the therapeutic potential of mebendazole (MBZ), a benzimidazole antiparasitic agent, as a repurposed drug for brain cancers, particularly glioblastoma and medulloblastoma. MBZ exerts anti-cancer effects by disrupting microtubule polymerization, inhibiting angiogenesis, inducing apoptosis, and modulating key oncogenic pathways such as Hedgehog signaling. Preclinical models demonstrate MBZ’s

Read More »
June 26, 2025 No Comments

Heterotopic Ossification: A Comprehensive Review

This 2019 comprehensive review discusses heterotopic ossification (HO), the pathological formation of bone in soft tissues. HO is often triggered by trauma, surgery, burns, or neurological injuries. The review covers clinical features, radiographic and histopathologic diagnosis, and treatment options, including NSAIDs, radiation therapy, and surgical excision. It also explores the

Read More »
June 26, 2025 No Comments

Addendum: Melatonin increases overall survival of prostate cancer patients with poor prognosis after combined hormone radiation treatment

This addendum investigates the role of melatonin in enhancing overall survival in prostate cancer patients with poor prognosis following combined hormone and radiation therapy. The study shows that melatonin improves patient outcomes by reducing side effects and enhancing the effectiveness of the treatments. It emphasizes melatonin’s potential as an adjunct

Read More »
June 26, 2025 No Comments

Betulinic acid derivatives NVX-207 and B10 for treatment of glioblastoma–an in vitro study of cytotoxicity and radiosensitization

This study investigates the cytotoxic effects and radiosensitizing potential of betulinic acid derivatives NVX-207 and B10 in the treatment of glioblastoma. The in vitro results show that both derivatives exhibit significant cytotoxicity against glioblastoma cells and enhance the effects of radiation therapy. The research suggests that these compounds may improve

Read More »
June 26, 2025 No Comments

Safety of Testosterone Therapy in Men with Prostate Cancer

This 2019 review by Morgentaler and Caliber examines the evolving perspective on testosterone therapy (TTh) in men with prostate cancer (PCa). Historically contraindicated, TTh is now considered a viable option for certain patients. The review discusses the “saturation model,” which suggests that prostate tissue’s response to androgens plateaus beyond a

Read More »
June 26, 2025 No Comments

Evaluation of quality of life in lung cancer patients receiving radiation and Viscum album L.: a real-world data study

This 2023 observational study (Radiation Oncology, PMID: 36879290) evaluated 112 lung cancer patients, primarily with non-small-cell lung cancer (median age 70), to assess the impact of adjunctive Viscum album L. (mistletoe) therapy on quality of life (QoL) during standard treatments, including radiation. Over 12 months, patients receiving radiation plus VA

Read More »
June 26, 2025 No Comments