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Tag: pulmonary hypertension

Anorexigens and Pulmonary Hypertension in the United States: Results from the Surveillance of North American Pulmonary Hypertension

This 2000 prospective surveillance study assessed the association between anorexigen use and pulmonary hypertension (PH) across 12 North American referral centers. Among 579 patients, 205 had primary pulmonary hypertension (PPH) and 374 had secondary PH (SPH). The study found a significant association between fenfluramine use and PPH, with an adjusted

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June 26, 2025 No Comments

Appetite-suppressant drugs and the risk of primary pulmonary hypertension?

This 1997 editorial by M. Deitel discusses findings from a multicenter case-control study involving 95 patients with primary pulmonary hypertension (PPH) and 355 matched controls. The study identified a significant association between the use of anorexic agents, particularly fenfluramine derivatives, and the development of PPH. The risk increased with longer

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June 26, 2025 No Comments

Role of DHEA in cardiovascular diseases

The article “Role of DHEA in cardiovascular diseases” (pubmed.ncbi.nlm.nih.gov) explores the potential of dehydroepiandrosterone (DHEA) as a therapeutic agent in cardiovascular conditions such as hypertension, coronary artery disease, atherosclerosis, and pulmonary hypertension. DHEA demonstrates anti-remodeling and vasorelaxant properties, mediated through membrane and nuclear receptors, ion channels, calcium signaling, and pathways

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June 26, 2025 No Comments