Well Referenced

Tag: PTSD

The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling: Implications for the Treatment of Depression, PTSD, and Suicidal Behaviors

This systematic review explores how specific nutrients—such as B vitamins (B6, B9, B12), omega-3 fatty acids, vitamin D, vitamin C, magnesium, zinc, and antioxidants—support mitochondrial function and neurotransmitter signaling, both of which are disrupted in mood disorders like depression, PTSD, and suicidal behavior. The review highlights that correcting nutritional deficiencies

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June 26, 2025 No Comments

Preventing the return of fear using reconsolidation updating and methylene blue is differentially dependent on extinction learning

This animal study explored how reconsolidation updating, a behavioral technique, and methylene blue (MB), a metabolic enhancer, could prevent the return of conditioned fear responses in rats. Reconsolidation updating broadly reduced fear reinstatement, while MB was effective specifically in rats responsive to extinction learning. These findings suggest potential clinical strategies

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June 26, 2025 No Comments

Extinction memory improvement by the metabolic enhancer methylene blue

This animal study examined the effects of methylene blue (MB), a metabolic enhancer, on extinction memory retention in rats. Results showed that MB-treated rats exhibited significantly lower freezing behavior in response to the conditioned stimulus, indicating improved retention of extinction memory. Additionally, MB increased brain cytochrome oxidase activity by 38%,

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June 26, 2025 No Comments

Systematic review and dosage analysis: hyperbaric oxygen therapy efficacy in the treatment of posttraumatic stress disorder

This systematic review evaluates the efficacy of hyperbaric oxygen therapy (HBOT) in treating posttraumatic stress disorder (PTSD), highlighting significant improvements in anxiety, depression, and hyperarousal symptoms. The studies reviewed included both military veterans and civilians with chronic PTSD, showing that HBOT at 1.5 atmospheres absolute (ATA) for 60 minutes over

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June 26, 2025 No Comments

The long-term costs of traumatic stress: intertwined physical and psychological consequences

This study explores the long-term impact of traumatic stress on both psychological and physical health, highlighting its role in neurobiological dysregulation, particularly through the hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system. PTSD is strongly linked to increased allostatic load, contributing to conditions such as chronic musculoskeletal pain, hypertension, hyperlipidemia, obesity,

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June 26, 2025 No Comments