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Tag: PTEN

Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1

This study investigated the pro-apoptotic effects of ursolic acid (UA) on human prostate cancer LNCaP cells. UA treatment resulted in significant inhibition of cell proliferation and induction of apoptosis, as evidenced by increased activities of caspase-3 and caspase-9. Mechanistically, UA activated the ROCK1/PTEN signaling pathway, leading to the dephosphorylation and

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June 26, 2025 No Comments

Calcium oxalate crystals trigger epithelial-mesenchymal transition and carcinogenic features in renal cells: a crossroad between kidney stone disease and renal cancer

This 2022 study explored the effects of calcium oxalate monohydrate (COM) crystals on non-cancerous renal cells. COM exposure induced epithelial-mesenchymal transition (EMT), characterized by morphological changes to a spindle shape, decreased epithelial markers (E-cadherin, ZO-1), and increased mesenchymal markers (fibronectin, vimentin). Additionally, COM downregulated tumor suppressor genes (ARID1A, PTEN, VHL)

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June 26, 2025 No Comments