Well Referenced

Tag: progesterone

Progestogen use in women approaching the menopause and breast cancer risk

This study investigates the neuroprotective effects of progesterone in a rat model of focal cerebral ischemia. The findings show that progesterone helps preserve mitochondrial function and reduce neuronal damage following reperfusion, suggesting that it could be a promising therapeutic option for mitigating stroke-related brain injury. By maintaining mitochondrial integrity and

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June 26, 2025 No Comments

Prostate cancer in men using testosterone supplementation

This study investigates the neuroprotective effects of progesterone (P4) in a rat model of ischemic stroke induced by transient middle cerebral artery occlusion (tMCAO). The results demonstrate that P4 significantly reduces infarct volume, preserves mitochondrial function, and decreases oxidative stress by inhibiting the mitochondrial permeability transition pore (mPTP). P4 also

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June 26, 2025 No Comments

Relationship between vasomotor symptom improvements and quality of life and sleep outcomes in menopausal women treated with oral, combined 17β-estradiol/progesterone

This phase 3, randomized controlled trial evaluated the effects of a combined 17β-estradiol and progesterone oral capsule (TX-001HR) on vasomotor symptoms (VMS), quality of life, and sleep in postmenopausal women. The study found that TX-001HR significantly reduced the frequency and severity of VMS, which was associated with improvements in quality

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June 26, 2025 No Comments

Effects of low-dose oral micronised progesterone on sleep, psychological distress, and breast development in transgender individuals undergoing feminising hormone therapy: a prospective controlled study

A prospective case-control study published in Endocrine Connections in 2022 (PMID: 35521814) investigated the effects of adding 100 mg oral micronized progesterone to existing estradiol therapy in transgender individuals undergoing feminizing hormone therapy. Over a 3-month period, 23 participants who started progesterone were compared to 19 controls who continued standard

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June 26, 2025 No Comments

Hormone therapy for the management of menopause symptoms

This article reviews hormone therapy as an effective treatment for managing vasomotor symptoms, such as hot flashes, during menopause. It highlights FDA-approved treatments that include estrogen alone or combined with progesterone, emphasizing their role in alleviating symptoms. The review discusses the importance of individualized treatment based on patient health status,

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June 26, 2025 No Comments

Improvement in sleep outcomes with a 17β-estradiol-progesterone oral capsule (TX-001HR) for postmenopausal women

TX-001HR, a combination of 17β-estradiol and progesterone, was evaluated in a randomized controlled trial for its effects on sleep quality in postmenopausal women experiencing vasomotor symptoms (VMS). The study included 1,835 participants (mean age 55) and tested four different dosages over 12 months. Results showed significant improvements in sleep quality,

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June 26, 2025 No Comments

Bioidentical hormone therapy: a review

This review evaluates bioidentical hormone therapy (BHT) for managing menopausal symptoms, comparing it to conventional hormone replacement therapy (HRT). While BHT may alleviate symptoms for some, evidence supporting its efficacy and safety is limited, and there is no clear advantage over traditional HRT. The review also highlights concerns with individualized

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June 26, 2025 No Comments

Bioidentical hormones for menopausal therapy

This review discusses the use of bioidentical hormones for menopausal therapy, criticizing the assumption that they are safer than synthetic hormones. Despite some proponents advocating for their use, particularly through salivary hormone testing, the review finds insufficient evidence to support their superiority or safety compared to synthetic options. Providers should

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June 26, 2025 No Comments

Absorption of Oral Progesterone is Influenced by Vehicle and Particle Size

This clinical trial examined how oral progesterone absorption is influenced by formulation, specifically particle size and vehicle type. Seven subjects received a 200 mg dose of progesterone in different formulations: plain milled, micronized, plain milled in oil, micronized in oil, and micronized in enteric-coated capsules. Serum progesterone levels were measured

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June 26, 2025 No Comments